作者
Marie Therese Cooney, Alexandra Dudina, Dirk De Bacquer, Anthony Fitzgerald, Ronan Conroy, Susana Sans, Alessandro Menotti, Guy De Backer, Pekka Jousilahti, Ulrich Keil, Troels Thomsen, Peter Whincup, Ian Graham, SCORE investigators
发表日期
2009/6/1
期刊
European Journal of Preventive Cardiology
卷号
16
期号
3
页码范围
304-314
出版商
Oxford University Press
简介
Background
Systematic COronary Risk Evaluation (SCORE), the risk estimation system recommended by the European guidelines on cardiovascular disease prevention, estimates 10-year risk of cardiovascular disease mortality based on age, sex, country of origin, systolic blood pressure, smoking status and either total cholesterol (TC) or TC/high-density lipoprotein cholesterol (HDL-C) ratio. As, counterintuitively, these two systems perform very similarly, we have investigated whether incorporating HDL-C and TC as separate variables improves risk estimation.
Methods
The study consisted of 57 302 men and 47 659 women. Cox proportional hazards method was used to derive the function including HDL-C and an identical function without HDL-C for comparison. Risk charts were developed to illustrate the results.
Results
Inclusion of HDL-C resulted in a …
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MT Cooney, A Dudina, D De Bacquer, A Fitzgerald… - European Journal of Preventive Cardiology, 2009