作者
Mohanraj Rajesh, Partha Mukhopadhyay, Sándor Bátkai, Vivek Patel, Keita Saito, Shingo Matsumoto, Yoshihiro Kashiwaya, Béla Horváth, Bani Mukhopadhyay, Lauren Becker, György Haskó, Lucas Liaudet, David A Wink, Aristidis Veves, Raphael Mechoulam, Pál Pacher
发表日期
2010/12/14
期刊
Journal of the American College of Cardiology
卷号
56
期号
25
页码范围
2115-2125
出版商
American College of Cardiology Foundation
简介
Objectives
In this study, we have investigated the effects of cannabidiol (CBD) on myocardial dysfunction, inflammation, oxidative/nitrative stress, cell death, and interrelated signaling pathways, using a mouse model of type I diabetic cardiomyopathy and primary human cardiomyocytes exposed to high glucose.
Background
Cannabidiol, the most abundant nonpsychoactive constituent of Cannabis sativa (marijuana) plant, exerts anti-inflammatory effects in various disease models and alleviates pain and spasticity associated with multiple sclerosis in humans.
Methods
Left ventricular function was measured by the pressure-volume system. Oxidative stress, cell death, and fibrosis markers were evaluated by molecular biology/biochemical techniques, electron spin resonance spectroscopy, and flow cytometry.
Results
Diabetic cardiomyopathy was characterized by declined diastolic and systolic myocardial performance …
学术搜索中的文章
M Rajesh, P Mukhopadhyay, S Bátkai, V Patel, K Saito… - Journal of the American College of Cardiology, 2010