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Although convincing evidence exists for the role of immunoglobulin G (IgG) antibodies in immunity to malaria, antibody titres do not usually predict protection. In this study we have assessed the interaction between Plasmodium falciparum-infected erythrocytes (PE), opsonized with immune serum containing different amounts of IgG antibody isotypes, with either THP-1 cells, ex-vivo human monocytes or IIAI.6 transfectant cells expressing FcγRIIa-Arg/Arg131 or –His/His131 allotypes. Our results show that PMA-treated THP-1 cells were capable of phagocytosing serum-opsonized PE by FcγRI (CD64) and FcγRIIa (CD32), acting synergistically. The known FcγRIIa polymorphism motivated us to examine its influence  on  IgG  isotype-mediated  phagocytosis  of  opsonized  PE  with  human  monocytes  and  the IIAI.6 transfectant cells expressing either allelic forms. Regardless of the cell type, PE …