作者
O Amengual, R Forastiero, M Sugiura-Ogasawara, K Otomo, K Oku, C Favas, J Delgado Alves, P Žigon, A Ambrožič, M Tomšič, I Ruiz-Arruza, G Ruiz-Irastorza, ML Bertolaccini, GL Norman, Z Shums, J Arai, A Murashima, AE Tebo, M Gerosa, PL Meroni, I Rodriguez-Pintó, R Cervera, J Swadzba, J Musial, T Atsumi
发表日期
2017/3
期刊
Lupus
卷号
26
期号
3
页码范围
266-276
出版商
SAGE Publications
简介
Objective
A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) might contribute to a better identification of antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted to ascertain the value of aPS/PT for APS diagnosis.
Methods
In the initial study (eight centres, seven countries), clinical/laboratory data were retrospectively collected. Serum/plasma samples were tested for IgG aPS/PT at Inova Diagnostics (Inova) using two ELISA kits. A replication study (five centres, five countries) was carried out afterwards.
Results
In the initial study (n = 247), a moderate agreement between the IgG aPS/PT Inova and MBL ELISA kits was observed (k = 0.598). IgG aPS/PT were more prevalent in APS patients (51%) than in those without (9 …
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O Amengual, R Forastiero, M Sugiura-Ogasawara… - Lupus, 2017