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Osteoarthritis (OA) is a chronic, degenerative joint disease marked by clinical symptoms and joint tissue deformation that predominantly harms joint cartilage, resulting in discomfort, edema, and stiffness near the joint (Jang, Lee, and Ju, 2021). The knee was known as the biggest synovial joint in humans which is made up of synovium, infrapatellar fat pad, ligaments, and bone components and experiences a lot of use and stress; making it a common location for painful disorders, notably OA (knee osteoarthritis; KOA)(Mora, Przkora, and Cruz-Almeida, 2018). KOA is a degenerative, inflammatory condition that affects knee joint and is accompanied by discomfort, impairment, and a lower quality of life (Vitaloni et al., 2019). Increased inflammatory activity has been associated with pain, eventhough the relationship level vary (Dainese et al., 2021). Almost 85% of OA incidences were correlated with KOA (Vos, T. et al., 2016). The prevalence of KOA among asymptomatic uninjured knees were ranging from 4–14% in less than 40 years age adults and 19–43% in adults aged 40 years and over (Culvenor et al., 2019).

Some conservative intervention options for KOA are exercise therapy, non-steroidal anti-inflammatory drugs (NSAIDs), and low-level anti-inflammatory laser therapy (LLLT). In comparison to standard care after 8 weeks, exercise dramatically reduces pain and enhances function, performance, and quality of life in persons with KOA (Goh et al., 2019) However, exercise therapy may be more beneficial for patients who are younger and are not in the waiting period for joint replacement. NSAIDs are recommended in most clinical treatment …