作者
Irina Bancos, Angela E Taylor, Vasileios Chortis, Alice J Sitch, Carl Jenkinson, Caroline J Davidge-Pitts, Katharina Lang, Stylianos Tsagarakis, Magdalena Macech, Anna Riester, Timo Deutschbein, Ivana D Pupovac, Tina Kienitz, Alessandro Prete, Thomas G Papathomas, Lorna C Gilligan, Cristian Bancos, Giuseppe Reimondo, Magalie Haissaguerre, Ljiljana Marina, Marianne A Grytaas, Ahmed Sajwani, Katharina Langton, Hannah E Ivison, Cedric HL Shackleton, Dana Erickson, Miriam Asia, Sotiria Palimeri, Agnieszka Kondracka, Ariadni Spyroglou, Cristina L Ronchi, Bojana Simunov, Danae A Delivanis, Robert P Sutcliffe, Ioanna Tsirou, Tomasz Bednarczuk, Martin Reincke, Stephanie Burger-Stritt, Richard A Feelders, Letizia Canu, Harm R Haak, Graeme Eisenhofer, M Conall Dennedy, Grethe A Ueland, Miomira Ivovic, Antoine Tabarin, Massimo Terzolo, Marcus Quinkler, Darko Kastelan, Martin Fassnacht, Felix Beuschlein, Urszula Ambroziak, Dimitra A Vassiliadi, Michael W O'Reilly, William F Young, Michael Biehl, Jonathan J Deeks, Wiebke Arlt, Stephan Glöckner, Richard O Sinnott, Anthony Stell, Maria C Fragoso, Ivana D Pupovac, Sarah Cazenave, Jérôme Bertherat, Rossella Libé, Christina Brugger, Stefanie Hahner, Matthias Kroiss, Cristina L Ronchi, Dimitra A Vassiliadi, Vittoria Basile, Elisa Ingargiola, Massimo Mannelli, Hester Ettaieb, Harm R Haak, Thomas M Kerkhofs, Richard A Feelders, Johannes Hofland, Leo J Hofland, Marianne A Grytaas, Eystein S Husebye, Grethe A Ueland, Malgorzata Zawierucha, Isabel Paiva, M Conall Dennedy, Mark Sherlock, Rachel K Crowley, Jonathan J Deeks, Alice J Sitch, Lorna C Giligan, Beverly A Hughes, Hannah E Ivison, Konstantinos Manolopoulos, Donna M O'Neil, Michael W O'Reilly, Thomas G Papathomas, Angela E Taylor, Robert P Sutcliffe, Peter Guest, Kassiani Skordilis, Alice Chang, Caroline J Davidge-Pitts, Danae A Delivanis, Neena Natt, Todd B Nippoldt, Melinda Thomas, William F Young Jr
发表日期
2020/9/1
期刊
The lancet Diabetes & endocrinology
卷号
8
期号
9
页码范围
773-781
出版商
Elsevier
简介
Background
Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion of adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity of imaging characteristics. We aimed to validate a urine steroid metabolomics approach, using steroid profiling as the diagnostic basis for ACC.
Methods
We did a prospective multicentre study in adult participants (age ≥18 years) with newly diagnosed adrenal masses. We assessed the accuracy of diagnostic imaging strategies based on maximum tumour diameter (≥4 cm vs <4 cm), imaging characteristics (positive vs negative), and urine steroid metabolomics (low, medium, or high risk of ACC), separately and in combination, using a reference standard of histopathology and follow-up investigations. With respect to imaging characteristics, we also assessed the diagnostic utility of increasing the unenhanced …
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I Bancos, AE Taylor, V Chortis, AJ Sitch, C Jenkinson… - The lancet Diabetes & endocrinology, 2020