作者
Jean-Philippe Empana, Chantal M Boulanger, Muriel Tafflet, Jean M Renard, Aurelie S Leroyer, Olivier Varenne, Christof Prugger, Johanne Silvain, Alain Tedgui, Alain Cariou, Gilles Montalescot, Xavier Jouven, Christian Spaulding
发表日期
2015/2/1
期刊
European Heart Journal: Acute Cardiovascular Care
卷号
4
期号
1
页码范围
28-36
出版商
Oxford University Press
简介
Aims
The pattern of coronary occlusion might contribute to the onset of ventricular arrhythmia and sudden cardiac death (SCD). We hypothesized that the concentrations of microparticles might differ between SCD and ST-elevation myocardial infarction (STEMI) patients without rhythmic disturbances.
Methods and results
The study sample includes consecutive patients hospitalized in two French tertiary centres between 2006 and 2011 for SCD with angiographically-proven acute coronary occlusion (n=23), for STEMI (n=61) and for a planned percutaneous coronary angioplasty (PCI) (n=35, controls). During PCI blood was collected in the arch of aorta (systemic blood) before and after the procedure and in the culprit coronary lesion with an aspiration catheter. Microparticles were analysed by flow cytometry in a blinded manner to quantify endothelial (CD144+), platelet (CD41 …
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JP Empana, CM Boulanger, M Tafflet, JM Renard… - European Heart Journal: Acute Cardiovascular Care, 2015