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To evaluate both velocity and spatial responses of velocity‐selective arterial spin labeling (VS‐ASL), using velocity‐insensitive and velocity‐compensated waveforms for control modules, as well as a novel dynamic phase‐cycling approach, at different B₀/ field inhomogeneities.

In the presence of imperfect refocusing, the mechanism of phase‐cycling the refocusing pulses through four dynamics was first theoretically analyzed with the conventional velocity‐selective saturation (VSS) pulse train. Numerical simulations were then deployed to compare the performance of the Fourier‐transform based velocity‐selective inversion (FT‐VSI) with these three different schemes in terms of both velocity and spatial responses under various B₀/ conditions. Phantom and human brain scans were performed to evaluate the three methods at scales of 0.8, 1.0, and 1.2.

The simulations of FT‐VSI showed …