作者
Sang eun Nam, Woosung Lim, Joon Jeong, Seeyoun Lee, Jungeun Choi, HeungKyu Park, Yong Sik Jung, Seung Pil Jung, Soo Youn Bae
发表日期
2019/10
期刊
Breast cancer research and treatment
卷号
177
页码范围
669-678
出版商
Springer US
简介
Purpose
Tumor markers such as carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) are widely used for monitoring breast cancer. However, the prognostic efficacy of preoperative elevations of CEA and CA15-3 levels in breast cancer patients remains controversial.
Methods
We retrospectively analyzed the clinicopathological parameters of 149,238 patients in the Korean Breast Cancer Society Registry Database who underwent surgery between January 2000 and December 2015.
Results
The patients with elevated CA15-3/CEA levels had worse overall survival (OS) than the patients with normal CA15-3/CEA levels. For the luminal A subtype, the CA15-3- and CEA-elevated group had a hazard ratio (HR) of 2.14 (95% CI 1.01–4.55). The CA15-3-elevated group had an HR of 2.38 (95% CI 1.58–3.58) and …
学术搜索中的文章
S Nam, W Lim, J Jeong, S Lee, J Choi, HK Park… - Breast cancer research and treatment, 2019