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The formation and accumulation of advanced glycation endproducts (AGEs) have been implicated in the pathogenesis of many chronic diseases, such as aging, Alzheimer’s disease, diabetes and diabetic complications. The present study was aimed to investigate the inhibitory effects of the extracts from nine microalgae on the formation of AGEs by using in vitro models and identify key antiglycation constituents of the microalgae. A BSA-glucose model with simulated physiological conditions was used to evaluate the inhibitory effect on total AGE formation. A BSA-MGO model was used to study the inhibitory activity against the dicarbonyl-induced AGE formation. The results showed that the aqueous acetone extracts exhibited stronger antiglycation activity than the other extracts (ethyl acetate and dichloromethane) and that the marine microalgal extracts were generally more effective than the freshwater ones. Their …