作者
Isabelle Touitou, Tamara Sarkisian, Myrna Medlej‐Hashim, Mehmet Tunca, Avi Livneh, Daniel Cattan, Fatos Yalçinkaya, Seza Özen, Hassan Majeed, Huri Ozdogan, Daniel Kastner, David Booth, Eldad Ben‐Chetrit, Denis Pugnere, Cécile Michelon, Fabienne Séguret, Ruth Gershoni‐Baruch, International Study Group for Phenotype‐Genotype Correlation in Familial Mediterranean Fever
发表日期
2007/5
期刊
Arthritis & Rheumatism
卷号
56
期号
5
页码范围
1706-1712
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
Familial Mediterranean fever (FMF), the prototype of autoinflammatory disorders, is caused by recessive mutations in the MEFV gene. Some FMF patients develop renal amyloidosis, a potentially fatal condition. This complication has mainly been associated with the M694V mutation, although the different study designs, small numbers of patients, and/or evaluation of few or no covariables calls this association into question. The aim of this study was to examine the controversial issue of amyloidosis susceptibility in FMF by determining the relative contributions of MEFV and numerous epidemiologic factors to the risk of renal amyloidosis.
Methods
Online questionnaires were completed at the MetaFMF database by patients at 35 centers in 14 countries. Using a standardized mode of data collection, we retrieved crude initial data from over half of the genetically confirmed FMF patients referred worldwide until …
引用总数
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I Touitou, T Sarkisian, M Medlej‐Hashim, M Tunca… - Arthritis & Rheumatism, 2007