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This research focused on the physical properties and cell compatibility of nanofibrous scaffolds based on polycaprolactone/chitosan (PCL/CTS) and PCL/carboxymethyl chitosan (PCL/CMC) blends for bone tissue engineering application. Scaffolds were fabricated by electrospinning technique. SEM images showed that the undesirable ultrafine and splitting fibers in PCL/CTS scaffolds are eliminated by replacing CTS with CMC. PCL/CMC scaffolds exposed significantly improved surface hydrophilicity improvement comparing to PCL/CTS ones. The water contact angle of PCL scaffold was reduced on the addition of 15% CMC from 123 ± 1° to 51 ± 3° in high concentration of CMC scaffold. The average diameter of fibers in PCL/CTS 15% and PCL/CMC 15% were 439 and 356 nm, respectively, which demonstrated higher concentrations of CMC resulted in decrease fibers diameter than other blended scaffolds …