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Stroke is a major global health burden with limited therapeutic options. Two major subtypes of stroke exist, ischaemic stroke (IS) and intracerebral haemorrhage (ICH). IS occurs following cerebrovascular occlusion, whereas ICH occurs when a vessel bursts and blood enters parenchymal brain tissue. The acute inflammatory response to both of these subtypes is thought to exacerbate neuronal injury and contribute to poor patient outcomes. The prototypical cytokine interleukin-1 (IL-1) sits at the apex of many inflammatory processes and a substantial amount of preclinical evidence strongly implicates IL-1 in IS pathogenesis. However, despite this, it is currently unclear whether IL-1 contributes to ICH pathophysiology. Thus, the primary aim of this doctoral thesis was to determine the contribution of IL-1 to ICH. Further, the canonical IL-1 family is composed of two distinct proteins, IL-1α and IL-1β, which require …