作者
Kamran A Abid, Oluwaseun A Sobowale, Laura M Parkes, Josephine Naish, Geoff JM Parker, Daniel du Plessis, David Brough, Jack Barrington, Stuart M Allan, Rainer Hinz, Adrian R Parry‐Jones
发表日期
2018/3
期刊
Journal of Neuroimaging
卷号
28
期号
2
页码范围
158-161
简介
BACKGROUND AND PURPOSE
Studies in animal models suggest that inflammation is a major contributor to secondary injury after intracerebral hemorrhage (ICH). Direct, noninvasive monitoring of inflammation in the human brain after ICH will facilitate early‐phase development of anti‐inflammatory treatments. We sought to investigate the feasibility of multimodality brain imaging in subacute ICH.
METHODS
Acute ICH patients were recruited to undergo multiparametric MRI (including dynamic contrast‐enhanced measurement of blood‐brain barrier transfer constant (Ktrans) and PET with [11C]‐(R)‐PK11195). [11C]‐(R)‐PK11195 binds to the translocator protein 18 kDa (TSPO), which is rapidly upregulated in activated microglia. Circulating inflammatory markers were measured at the time of PET.
RESULTS
Five patients were recruited to this feasibility study with imaging between 5 and 16 days after onset …
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KA Abid, OA Sobowale, LM Parkes, J Naish… - Journal of Neuroimaging, 2018