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Previous literature reports suggest that tissue stiffness is a predictor of cancer and metastatic behavior. We have used optical coherence tomography and vibrational analysis (VOCT) to characterize normal skin, scar, a basal cell carcinoma and an actinic keratosis non-invasively and non-destructively.

It is concluded that enhanced VOCT images of surface roughness and lesion morphology in combination with estimates of cellular and collagen content may assist the clinician in better characterizing different skin lesions prior to excision. The use of VOCT in the physician’s office will assist the surgeon in preoperative planning and facilitate patient treatment that will benefit both the doctor and patient.