作者
Daniel J Smith, Valentina Escott-Price, Gail Davies, Mark ES Bailey, Lucía Colodro-Conde, Joey Ward, Alexey Vedernikov, Riccardo Marioni, Breda Cullen, Donald Lyall, Saskia P Hagenaars, David CM Liewald, Michelle Luciano, Catharine R Gale, Stuart J Ritchie, Caroline Hayward, Barbara Nicholl, Brendan Bulik-Sullivan, Mark Adams, Baptiste Couvy-Duchesne, Nicholas Graham, Daniel Mackay, Jonathan Evans, Blair H Smith, David J Porteous, SE Medland, Nick G Martin, Peter Holmans, Andrew M McIntosh, Jill P Pell, Ian J Deary, MC O'Donovan
发表日期
2016/6
期刊
Molecular psychiatry
卷号
21
期号
6
页码范围
749-757
出版商
Nature Publishing Group
简介
Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although neuroticism is heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes. Here we report a combined meta-analysis of genome-wide association study (GWAS) of neuroticism that includes 91 370 participants from the UK Biobank cohort, 6659 participants from the Generation Scotland: Scottish Family Health Study (GS: SFHS) and 8687 participants from a QIMR (Queensland Institute of Medical Research) Berghofer Medical Research Institute (QIMR) cohort. All participants were assessed using the same neuroticism instrument, the Eysenck Personality Questionnaire-Revised (EPQ-RS) Short Form’s Neuroticism scale. We found a single …
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DJ Smith, V Escott-Price, G Davies, MES Bailey… - Molecular psychiatry, 2016