作者
Mahmoud Reza Azarpazhooh, Abolfazl Avan, Lauren E Cipriano, David G Munoz, Luciano A Sposato, Vladimir Hachinski
发表日期
2018/2/1
来源
Alzheimer's & Dementia
卷号
14
期号
2
页码范围
148-156
出版商
No longer published by Elsevier
简介
Introduction
The relative contributions of vascular and degenerative pathology to dementia are unknown. We aim to quantify the proportion of dementia explained by potentially preventable vascular lesions.
Methods
We systematically searched for population-based cohorts before February 2017 reporting clinicopathological data for individuals with and without dementia. We calculated the summary proportion and absolute risk of dementia comparing subjects with and without the pathology.
Results
We identified 10 studies comprising 2856 subjects. Vascular-type pathology and mixed pathology are respectively two and three times more likely in demented patients. The summary proportion of dementia is 77%–86% in subjects with mixed degenerative and vascular pathology and 45% in subjects with pure Alzheimer-type pathology.
Discussion
Patients with mixed pathologies have nearly twice the incremental risk of …
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MR Azarpazhooh, A Avan, LE Cipriano, DG Munoz… - Alzheimer's & Dementia, 2018