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Objectives:

Describe a single center experience of hemophagocytic lymphohistiocytosis in a PICU over a 10-year period, to identify clinical features that may be associated with worse outcomes, including mortality, hospital and ICU length of stay, and functional and cognitive impairments on discharge.

Design:

Retrospective electronic medical record review, 2007–2017.

Setting:

PICU located in a large urban academic quaternary care children’s hospital.

Patients:

All children admitted with hemophagocytic lymphohistiocytosis to our PICU from 2007 to 2017.

Interventions:

None.

Measurements and Main Results:

All patients were identified utilizing International Classification of Diseases, 9th Revision and International Classification of Diseases, 10th Revision codes. Each chart was reviewed for demographic information, hemophagocytic lymphohistiocytosis diagnostic criteria, laboratory data, Pediatric Risk of Mortality Score …