作者
Nancy Leymarie, Paula J Griffin, Karen Jonscher, Daniel Kolarich, Ron Orlando, Mark McComb, Joseph Zaia, Jennifer Aguilan, William R Alley, Friederich Altmann, Lauren E Ball, Lipika Basumallick, Carthene R Bazemore-Walker, Henning Behnken, Michael A Blank, Kristy J Brown, Svenja-Catharina Bunz, Christopher W Cairo, John F Cipollo, Rambod Daneshfar, Heather Desaire, Richard R Drake, Eden P Go, Radoslav Goldman, Clemens Gruber, Adnan Halim, Yetrib Hathout, Paul J Hensbergen, David M Horn, Deanna Hurum, Wolfgang Jabs, Göran Larson, Mellisa Ly, Benjamin F Mann, Kristina Marx, Yehia Mechref, Bernd Meyer, Uwe Möginger, Christian Neusüβ, Jonas Nilsson, Milos V Novotny, Julius O Nyalwidhe, Nicolle H Packer, Petr Pompach, Bela Reiz, Anja Resemann, Jeffrey S Rohrer, Alexandra Ruthenbeck, Miloslav Sanda, Jan Mirco Schulz, Ulrike Schweiger-Hufnagel, Carina Sihlbom, Ehwang Song, Gregory O Staples, Detlev Suckau, Haixu Tang, Morten Thaysen-Andersen, Rosa I Viner, Yanming An, Leena Valmu, Yoshinao Wada, Megan Watson, Markus Windwarder, Randy Whittal, Manfred Wuhrer, Yiying Zhu, Chunxia Zou
发表日期
2013/10/1
期刊
Molecular & Cellular Proteomics
卷号
12
期号
10
页码范围
2935-2951
出版商
Elsevier
简介
One of the principal goals of glycoprotein research is to correlate glycan structure and function. Such correlation is necessary in order for one to understand the mechanisms whereby glycoprotein structure elaborates the functions of myriad proteins. The accurate comparison of glycoforms and quantification of glycosites are essential steps in this direction. Mass spectrometry has emerged as a powerful analytical technique in the field of glycoprotein characterization. Its sensitivity, high dynamic range, and mass accuracy provide both quantitative and sequence/structural information. As part of the 2012 ABRF Glycoprotein Research Group study, we explored the use of mass spectrometry and ancillary methodologies to characterize the glycoforms of two sources of human prostate specific antigen (PSA). PSA is used as a tumor marker for prostate cancer, with increasing blood levels used to distinguish between normal …
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N Leymarie, PJ Griffin, K Jonscher, D Kolarich… - Molecular & Cellular Proteomics, 2013