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This paper reviews the diversity of relationships between river evolution and karstogenesis. It also underlines the fundamental role of numerical dating methods (e.g. cosmogenic nuclides) applied to sedimentary sequences in tiered cave passages as they have provided new insights into these complex interactions. Although karst terrain is widespread worldwide, we focus on European karst catchments, where the sedimentary records are especially well preserved. We review the recent dating of fluvial sediments and speleothems, to examine the timing of karstification, incision and deposition in cave levels. The most complete alluvial records occur in tectonically uplifted high mountains where some of the oldest sediment fills date to the Miocene. Evidence indicates that not only uplift, but also climatic conditions and fluvial dynamics (e.g. knickpoint retreat, increased channel flow and/or sediment load, and stream …