作者
Simon M Collin, Chris Metcalfe, Helga Refsum, Sarah J Lewis, Luisa Zuccolo, George Davey Smith, Lina Chen, Ross Harris, Michael Davis, Gemma Marsden, Carole Johnston, J Athene Lane, Marta Ebbing, Kaare Harald Bønaa, Ottar Nygård, Per Magne Ueland, Maria V Grau, John A Baron, Jenny L Donovan, David E Neal, Freddie C Hamdy, A David Smith, Richard M Martin
发表日期
2010/6/1
来源
Cancer epidemiology, biomarkers & prevention
卷号
19
期号
6
页码范围
1632-1642
出版商
American Association for Cancer Research
简介
Background: Disturbed folate metabolism is associated with an increased risk of some cancers. Our objective was to determine whether blood levels of folate, vitamin B12, and related metabolites were associated with prostate cancer risk.
Methods: Matched case-control study nested within the U.K. population–based Prostate testing for cancer and Treatment (ProtecT) study of prostate-specific antigen–detected prostate cancer in men ages 50 to 69 years. Plasma concentrations of folate, B12 (cobalamin), holo-haptocorrin, holo-transcobalamin total transcobalamin, and total homocysteine (tHcy) were measured in 1,461 cases and 1,507 controls. ProtecT study estimates for associations of folate, B12, and tHcy with prostate cancer risk were included in a meta-analysis, based on a systematic review.
Results: In the ProtecT study, increased B12 and holo-haptocorrin concentrations …
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SM Collin, C Metcalfe, H Refsum, SJ Lewis, L Zuccolo… - Cancer epidemiology, biomarkers & prevention, 2010