作者
Simon Gilbody, Sarah Lewis, Tracy Lightfoot
发表日期
2007/1/1
来源
American journal of epidemiology
卷号
165
期号
1
页码范围
1-13
出版商
Oxford University Press
简介
The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia. The primary comparison was between homozygote variants and the wild type for MTHFR C677T and A1298C. For unipolar depression and the MTHFR C677T polymorphism, the fixed-effects odds ratio for homozygote variants (TT) versus the wild type (CC) was 1.36 (95% confidence interval (CI): 1.11, 1.67), with no residual between-study heterogeneity (I2 = 0%)—based on 1,280 cases and 10,429 controls. For schizophrenia and MTHFR C677T, the fixed-effects odds ratio for TT versus CC was 1.44 (95% CI: 1.21, 1.70), with low heterogeneity (I2 = 42%)—based on 2,762 cases and 3 …
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S Gilbody, S Lewis, T Lightfoot - American journal of epidemiology, 2007