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Eight 3 ß, 5ot, 6ß-trihydroxysterols [1-8], of which four [1, 2, 7, and 8} are new, have been isolated from the spongeSpongionella gracilis and their structures deduced by spectroscopic and chemical evidence.

Polyhydroxylated sterols are common metabolites in marine invertebrates such as gorgonians and alcyonarians (1-3), whereas they seem more rare in sponges (4-6). Re-cently we isolated from the sponge Spongionella gracilis Vosmaer (order Dyctioceratida, family Dysideidae) three new 3ß, 6a-dihydroxysterols (7). A further investigation of the lipidie extract of the same organism yielded a mixture of the 3 ß, 5ot, 63-trihydroxy-sterols described in this paper.