作者
Thomas D Otto, Ulrike Böhme, Andrew P Jackson, Martin Hunt, Blandine Franke-Fayard, Wieteke AM Hoeijmakers, Agnieszka A Religa, Lauren Robertson, Mandy Sanders, Solabomi A Ogun, Deirdre Cunningham, Annette Erhart, Oliver Billker, Shahid M Khan, Hendrik G Stunnenberg, Jean Langhorne, Anthony A Holder, Andrew P Waters, Chris I Newbold, Arnab Pain, Matthew Berriman, Chris J Janse
发表日期
2014/12
期刊
BMC biology
卷号
12
页码范围
1-18
出版商
BioMed Central
简介
Background
Rodent malaria parasites (RMP) are used extensively as models of human malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA (PbA) and P. chabaudi AS (PcAS). Although availability of these genomes made a significant impact on recent malaria research, these genomes were highly fragmented and were annotated with little manual curation. The fragmented nature of the genomes has hampered genome wide analysis of Plasmodium gene regulation and function.
Results
We have greatly improved the genome assemblies of PbA and PcAS, newly sequenced the virulent parasite P. yoelii YM genome, sequenced additional RMP isolates/lines and have characterized genotypic diversity within RMP species. We have produced RNA-seq data and utilised it to improve gene-model prediction and to provide …
学术搜索中的文章
TD Otto, U Böhme, AP Jackson, M Hunt… - BMC biology, 2014