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We validate a miniaturized pulsed laser source for use in time-domain (TD) diffuse optics, following rigorous and shared protocols for performance assessment of this class of devices. This compact source () has been previously developed for range finding applications and is able to provide short, high energy (, ) optical pulses at up to 1 MHz repetition rate. Here, we start with a basic level laser characterization with an analysis of suitability of this laser for the diffuse optics application. Then, we present a TD optical system using this source and its performances in both recovering optical properties of tissue-mimicking homogeneous phantoms and in detecting localized absorption perturbations. Finally, as a proof of concept of in vivo application, we demonstrate that the system is able to detect hemodynamic changes occurring in the arm of healthy volunteers during a venous occlusion …