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Vaccines are regarded as the most successful and cost-effective medical interventions to-date. They have the capacity to instruct the immune system on how to clear or prevent infections. This is accomplished by harnessing the same immune mechanisms that fight natural infections and generate immunological memory to more rapidly clear pathogens upon re-exposure. Historically, vaccines have largely been developed through empirical methods, yet numerous pathogens have evaded the standard vaccine strategies and pose significant challenges that require new approaches to vaccine development. Today, the majority of licensed vaccines provide protection through the elicitation of antibody (Ab) responses that can neutralize or help clear specific pathogens [1]. The quality and durability of elicited Ab responses vary widely between vaccines, a dilemma that is still not fully understood [2]. Non-live vaccines are …