作者
L Puybasset, JJ Rouby, E Mourgeon, TE Stewart, P Cluzel, M Arthaud, P Poete, L Bodin, AM Korinek, P Viars
发表日期
1994/5
期刊
Intensive care medicine
卷号
20
页码范围
319-327
出版商
Springer-Verlag
简介
Objective
To determine the dose-response curve of inhaled nitric oxide (NO) in terms of pulmonary vasodilation and improvement in PaO2 in adults with severe acute respiratory failure.
Design
Prospective randomized study.
Setting
A 14-bed ICU in a teaching hospital.
Patients
6 critically ill patients with severe acute respiratory failure (lung injury severity score ≥2.5) and pulmonary hypertension.
Interventions
8 concentrations of inhaled NO were administered at random: 100, 400, 700, 1000, 1300, 1600, 1900 and 5000 parts per billion (ppb). Control measurements were performed before NO inhalation and after the last concentration administered. After an NO exposure of 15–20 min, hemodynamic parameters obtained from a fiberoptic Swan-Ganz …
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