作者
Ronald Chow, David G Warr, Rudolph M Navari, May Tsao, Marko Popovic, Leonard Chiu, Milica Milakovic, Henry Lam, Carlo DeAngelis
发表日期
2018/8/1
期刊
Supportive Care in Cancer
卷号
26
页码范围
2519-2549
简介
Purpose
Chemotherapy-induced nausea and vomiting (CINV) continues to be a common side effect of systemic anticancer therapy, decreasing quality of life and increasing resource utilization. The aim of this meta-analysis was to investigate the comparative efficacy and safety of palonosetron relative to other 5-HT3RAs.
Methods
A literature search was carried out in Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials. Full-text references were then screened and included in this meta-analysis if they were an RCT and had adequate data regarding one of the five primary endpoints—complete response (CR), complete control (CC), no emesis, no nausea, or no rescue medications.
Results
A total of 24 RCTs were included in this review. Palonosetron was statistically superior to other 5-HT3RAs for …
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R Chow, DG Warr, RM Navari, M Tsao, M Popovic… - Supportive Care in Cancer, 2018