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It was with great interest that we read the research article by Wang et al. In their manuscript, the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) particles in hepatocytes is shown with additional arguments for viral replication and cytopathy in infected hepatocytes, which provides a partial explanation for the high prevalence of abnormal liver laboratory tests in patients with COVID-19. 1 It has already been proposed that SARS-CoV-2 might directly infect liver cells. 2 It certainly seemed that a risk stratification for direct liver cell infection could be predicted based on single cell transcriptomic data for the SARS-CoV-2 entry factors ACE2 (SARS-CoV-2 cellular entry) and TMPRSS2 (spike protein priming). 3 Many researchers have analyzed single cell RNA sequencing (scRNASeq) datasets. The general conclusion was that the liver is a low-risk organ for SARS-CoV-2 infection, 4 though …