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Leiomyosarcoma is a malignant smooth-muscle tumor that is exceedingly rare in the head and neck region. Two cases of this uncommon tumor localized in the larynx and the parapharyngeal region are presented in this report, which might be the second leiomyosarcoma in the parapharyngeal region reported so far to our knowledge. We also discuss the diagnosis and treatment of leiomyosarcoma in this aspect.