作者
Lars Ivo Partecke, Katja Evert, Jan Haugk, Friderike Doering, Lars Normann, Stephan Diedrich, Frank-Ulrich Weiss, Matthias Evert, Nils Olaf Huebner, Cristin Guenther, Claus Dieter Heidecke, Axel Kramer, René Bussiahn, Klaus-Dieter Weltmann, Onur Pati, Claudia Bender, Wolfram von Bernstorff
发表日期
2012/12
期刊
BMC cancer
卷号
12
页码范围
1-10
出版商
BioMed Central
简介
Background
The rate of microscopic incomplete resections of gastrointestinal cancers including pancreatic cancer has not changed considerably over the past years. Future intra-operative applications of tissue tolerable plasmas (TTP) could help to address this problem. Plasma is generated by feeding energy, like electrical discharges, to gases. The development of non-thermal atmospheric plasmas displaying spectra of temperature within or just above physiological ranges allows biological or medical applications of plasmas.
Methods
We have investigated the effects of tissue tolerable plasmas (TTP) on the human pancreatic cancer cell line Colo-357 and PaTu8988T and the murine cell line 6606PDA in vitro (Annexin-V-FITC/DAPI-Assay and propidium iodide DNA staining assay) as well as in the in vivo tumour chorio-allantoic membrane (TUM-CAM …
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