作者
Mohammad Sadegh Soltan-Sharifi, Mojtaba Mojtahedzadeh, Atabak Najafi, Mohammad Reza Khajavi, Mohammad Reza Rouini, Mandana Moradi, Azadeh Mohammadirad, Mohammad Abdollahi
发表日期
2007/9
期刊
Human & experimental toxicology
卷号
26
期号
9
页码范围
697-703
出版商
Sage Publications
简介
In acute respiratory distress syndrome (ARDS), there is extensive overproduction of free radicals to the extent that endogenous anti-oxidants are overwhelmed, permitting oxidative cell damage. The present study examined the benefit of the anti-oxidant compound N-acetylcysteine (NAC) in the management of ARDS by measuring patient's intracellular glutathione (inside red blood cells) and extracellular (plasma) anti-oxidant defense biomarkers and outcome. Twenty-seven ARDS patients were recruited from the intensive care unit of a teaching Hospital and randomly divided into two groups. Both groups were managed similarly by regular treatments but 17 patients received NAC 150 mg/kg at the first day that followed by 50 mg/kg/day for three days and 10 patients did not receive NAC. Treatment by NAC …
引用总数
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