作者
Mahmoud Barbarawi, Yazan Zayed, Babikir Kheiri, Inderdeep Gakhal, Owais Barbarawi, Areeg Bala, Ahmad Alabdouh, Ahmed Abdalla, Fatima Rizk, Ghassan Bachuwa, Khalil Katato
发表日期
2019/9/1
来源
Thrombosis Research
卷号
181
页码范围
36-45
出版商
Pergamon
简介
Background
Venous thromboembolism (VTE) is a common cause of morbidity and mortality among patients with cancer. As such, we conducted a meta-analysis of randomized controlled trials (RCTs) that evaluated anticoagulants as primary prophylaxis against VTE in cancer patients.
Methods
Pubmed/MEDLINE, Embase, and the Cochrane Library were screened for all RCTs that used anticoagulation therapy in cancer patients for primary prevention of VTE. The primary outcomes were VTE events. Secondary outcomes included all-cause mortality, VTE-related mortality and major bleeding. A random effects model was used to report the risk ratios (RR) with 95% confidence intervals (CIs), and odds ratios (ORs) with Bayesian 95% credible intervals for both direct and network meta-analyses, respectively.
Results
Twenty-four RCTs were included totaling 13,338 patients (7197 received anticoagulation and 6141 …
学术搜索中的文章
M Barbarawi, Y Zayed, B Kheiri, I Gakhal, O Barbarawi… - Thrombosis Research, 2019