作者
Yan Li, Radhika Srinivasan, Helene Ratiney, Ying Lu, Susan M Chang, Sarah J Nelson
发表日期
2008/8
期刊
Journal of Magnetic Resonance Imaging: An Official Journal of the International Society for Magnetic Resonance in Medicine
卷号
28
期号
2
页码范围
342-350
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Purpose
To measure T1 and T2 relaxation times of metabolites in glioma patients at 3T and to investigate how these values influence the observed metabolite levels.
Materials and Methods
A total of 23 patients with gliomas and 10 volunteers were studied with single‐voxel two‐dimensional (2D) J‐resolved point‐resolved spectral selection (PRESS) using a 3T MR scanner. Voxels were chosen in normal appearing white matter (WM) and in regions of tumor. The T1 and T2 of choline containing compounds (Cho), creatine (Cr), and N‐acetyl aspartate (NAA) were estimated.
Results
Metabolite T1 relaxation values in gliomas were not significantly different from values in normal WM. The T2 of Cho and Cr were statistically significantly longer for grade 4 gliomas than for normal WM but the T2 of NAA was similar. These differences were large enough to impact the corrections of metabolite levels for relaxation times …
引用总数
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Y Li, R Srinivasan, H Ratiney, Y Lu, SM Chang… - Journal of Magnetic Resonance Imaging: An Official …, 2008