作者
Bruno T Sedassari, Harim T Dos Santos, Fernanda M Pigatti, Maria C Martins Mussi, Priscila L Tobouti, Albina Altemani, Suzana Sousa
发表日期
2016/6
期刊
Histopathology
卷号
68
期号
7
页码范围
1046-1054
简介
Aims
The diagnosis of polymorphous low‐grade adenocarcinoma (PLGA) remains difficult for general pathologists, particularly in cases of small biopsy samples. We aimed to characterize the histopathological spectrum and immunohistochemical aspects by using an accessible immunohistochemical panel of cytoskeletal proteins in limited samples of PLGA.
Methods and results
Forty‐six patients diagnosed with PLGA in incisional biopsies were identified retrospectively. Seventy‐two per cent of patients were women and 28% were men, with a mean age of 55 years. The palate was the most affected site. Grossly, the mean size of the samples was 0.8 cm and 74% of specimens were fragmented. All tumours characteristically displayed the microscopic features of architecturally diverse patterns, infiltrative areas and low‐grade cytology. Neoplastic cells were diffusely positive to cytokeratin (CK) 7, vimentin and S100 …
引用总数
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