作者
Mingzhao Xing, William H Westra, Ralph P Tufano, Yoram Cohen, Eli Rosenbaum, Kerry J Rhoden, Kathryn A Carson, Vasily Vasko, Alexandr Larin, Giovanni Tallini, Sara Tolaney, Elizabeth H Holt, Pei Hui, Christopher B Umbricht, Shehzad Basaria, Marge Ewertz, Anthony P Tufaro, Joseph A Califano, Matthew D Ringel, Martha A Zeiger, David Sidransky, Paul W Ladenson
发表日期
2005/12/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
90
期号
12
页码范围
6373-6379
出版商
Oxford University Press
简介
Context: Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve risk stratification of this cancer.
Objective: The objective of the study was to investigate the prognostic value of BRAF mutation in patients with PTC.
Design, Setting, and Subjects: In a multicenter study of 219 PTC patients, data on their clinicopathological characteristics and clinical courses between 1990 and 2004 were retrospectively collected, and their tumor BRAF mutation status was determined. Associations of BRAF mutation with initial tumor characteristics and subsequent recurrence were analyzed.
Main Outcome Measure: Relationships between the BRAF mutation status and clinicopathological outcomes, including recurrence, were measured.
Results: We found a significant association between BRAF mutation and extrathyroidal invasion (P < 0.001), lymph node …
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M Xing, WH Westra, RP Tufano, Y Cohen… - The Journal of Clinical Endocrinology & Metabolism, 2005