查看文章

There has been increased interest in the use of dietary ingredients, including prebiotics such as human‐milk oligosaccharides (HMOs), as therapeutic strategies for food allergy. Understanding the mechanisms underlying the beneficial effects of HMOs is important to realizing their therapeutic potential.

Here we demonstrate that the HMO, 6’‐sialyllactose (6’SL) inhibited chemokine (IL‐8 and CCL20) release from T‐84 and HT‐29 cells stimulated with antigen–antibody complex, TNFα or PGE₂; an effect that was PPARγ dependent and associated with decreased activity of the transcription factors AP‐1 and NFκB. In contrast, 2’‐fucosyllactose (2’FL) selectively inhibited CCL20 release in response to antigen antibody complex in a PPARγ independent manner.

This study reinforces the concept that structurally different oligosaccharides have distinct biological activities and identifies, for the first time, that the …