作者
Muhammad Mamdani, Paula Rochon, David N Juurlink, Geoffrey M Anderson, Alex Kopp, Gary Naglie, Peter C Austin, Andreas Laupacis
发表日期
2003/2/24
期刊
Archives of internal medicine
卷号
163
期号
4
页码范围
481-486
出版商
American Medical Association
简介
Background
Recent debate has emerged regarding the cardiovascular safety of selective cyclooxygenase 2 inhibitors and the possible cardioprotective effect of naproxen sodium. We compared the rates of acute myocardial infarction (AMI) among elderly patients dispensed selective cyclooxygenase 2 inhibitors, naproxen, and nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs).
Methods
We conducted a population-based retrospective cohort study using administrative health care data from Ontario, Canada, from April 1, 1998, to March 31, 2001. We identified NSAID-naive cohorts of subjects aged 66 years and older in whom treatment was initiated with celecoxib (n = 15 271), rofecoxib (n = 12 156), naproxen (n = 5669), and nonnaproxen nonselective NSAIDs (n = 33 868), along with a randomly selected control cohort not exposed to NSAIDs (n = 100 000). Multivariate Cox proportional …
引用总数
学术搜索中的文章
M Mamdani, P Rochon, DN Juurlink, GM Anderson… - Archives of internal medicine, 2003