作者
Adrian W Laxton, David F Tang‐Wai, Mary Pat McAndrews, Dominik Zumsteg, Richard Wennberg, Ron Keren, John Wherrett, Gary Naglie, Clement Hamani, Gwenn S Smith, Andres M Lozano
发表日期
2010/10
期刊
Annals of neurology
卷号
68
期号
4
页码范围
521-534
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
Alzheimer disease (AD) is characterized by functional impairment in the neural elements and circuits underlying cognitive and memory functions. We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits.
Methods
We conducted a phase I trial in 6 patients with mild AD receiving ongoing medication treatment. Patients received continuous stimulation for 12 months. Three main lines of investigation were pursued including: (1) mapping the brain areas whose physiological function was modulated by stimulation using standardized low‐resolution electromagnetic tomography, (2) assessing whether DBS could correct the regional alterations in cerebral glucose metabolism in AD using positron emission tomography (PET), and 3) measuring the effects of DBS on cognitive function …
引用总数
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AW Laxton, DF Tang‐Wai, MP McAndrews, D Zumsteg… - Annals of neurology, 2010