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A total 37 pati ents suffering from end stage-IV Fontaine (CLI and di abetic fo ot) with an ulcerated limb in whom all previ o us therape utic strategi es failed (eg surgical revascularizati on and endovascular repair) were selected and underwent local transplantati on of Autologo us Bone Marrow Stem Cells (ABMSCs). The efficacy/safety of this therapy was assessed by using several endpo ints such as (a) preventi on of amputati on,(b) wo und he aling and (c) degree of angi ogenesis. In order to assess the limb ischemi a and hypoxi a the several tests and me asurements were performed pre-and post transplantati on at a vari ety of time intervals. The me asurements include: TP-toe pressure me asurements (by Periflux 5000 Laser Doppler and Oxymetry system), SPP-skin perfusi on pressure, ABI-ankle brachi al index, LDP-Laser Doppler baseline and he at perfusi on assessment, TcpO2 witho ut and with O2 provocati …