作者
Smitha Karavallil Achuthan, Kelly L Coburn, Meagan E Beckerson, Rajesh K Kana
发表日期
2023/1
期刊
Autism Research
卷号
16
期号
1
页码范围
84-98
出版商
John Wiley & Sons, Inc.
简介
Resting state fMRI (rs‐fMRI) provides an excellent platform for examining the amplitude of low frequency fluctuations (ALFF) and fractional amplitude of low frequency fluctuations (fALFF), which are key indices of brain functioning. However, ALFF and fALFF have been used only sporadically to study autism. rs‐fMRI data from 69 children (40 autistic, mean age = 8.47 ± 2.20 years; age range: 5.2 to 13.2; and 29 non‐autistic, mean age = 9.02 ± 1.97 years; age range 5.9 to 12.9) were obtained from the Autism Brain Imaging Data Exchange (ABIDE II). ALFF and fALFF were measured using CONN connectivity toolbox and SPM12, at whole‐brain & network‐levels. A two‐sampled t‐test and a 2 Group (autistic, non‐autistic) × 7 Networks ANOVA were conducted to test group differences in ALFF and fALFF. The whole‐brain analysis identified significantly reduced ALFF values for autistic participants in left parietal …
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