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Objective: To measure the blood flow distribution and regional oxygen transport in hyperdynamic septic shock during hypotension and after correction by vasopressor doses of dopamine or norepinephrine.

Design: Prospective, randomized, controlled trial.

Setting: Tertiary care center.

Patients: Ten patients with hyperdynamic septic shock (ages ranging from 45.1+/-16.6 yrs) and a control group of 11 postoperative cardiac surgery patients (ages ranging from 54.8+/-7.9 yrs).

Interventions: Systemic and regional hemodynamics and oxygen transport were measured in ten patients with hyperdynamic septic shock during hypotension and after vasopressor therapy (norepinephrine or dopamine). Oxygen consumption (Vo2) was measured by indirect calorimetry and splanchnic and leg blood flow with indocyanine green infusion.

Measurements and Main Results: Splanchnic blood flow and (Vo2 (p<. 05) were increased in …