作者
Marieke J Bart, Simon R Harris, Abdolreza Advani, Yoshichika Arakawa, Daniela Bottero, Valérie Bouchez, Pamela K Cassiday, Chuen-Sheue Chiang, Tine Dalby, Norman K Fry, María Emilia Gaillard, Marjolein Van Gent, Nicole Guiso, Hans O Hallander, Eric T Harvill, Qiushui He, Han GJ Van der Heide, Kees Heuvelman, Daniela F Hozbor, Kazunari Kamachi, Gennady I Karataev, Ruiting Lan, Anna Lutyńska, Ram P Maharjan, Jussi Mertsola, Tatsuo Miyamura, Sophie Octavia, Andrew Preston, Michael A Quail, Vitali Sintchenko, Paola Stefanelli, M Lucia Tondella, Raymond SW Tsang, Yinghua Xu, Shu-Man Yao, Shumin Zhang, Julian Parkhill, Frits R Mooi
发表日期
2014/5/1
期刊
MBio
卷号
5
期号
2
页码范围
10.1128/mbio. 01074-14
出版商
American Society for Microbiology
简介
Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant mortality in infants. Possible causes for this include the switch from whole-cell vaccines (WCVs) to less effective acellular vaccines (ACVs), waning immunity, and pathogen adaptation. Pathogen adaptation is suggested by antigenic divergence between vaccine strains and circulating strains and by the emergence of strains with increased pertussis toxin production. We applied comparative genomics to a worldwide collection of 343 B. pertussis strains isolated between 1920 and 2010. The global phylogeny showed two deep branches; the largest of these contained 98% of all strains, and its expansion correlated temporally with the first descriptions of pertussis outbreaks in Europe in the 16th century …
学术搜索中的文章
MJ Bart, SR Harris, A Advani, Y Arakawa, D Bottero… - MBio, 2014