作者
Xinlong Wang, Wei Song, Naoki Kawazoe, Guoping Chen
发表日期
2013/12
期刊
Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials
卷号
101
期号
12
页码范围
3388-3395
简介
Cell–cell interaction plays an important role in the control of cell functions. The precise control of cell–cell interaction will provide a useful tool to elucidate its influence on stem cell differentiation. In this study, four types of micropatterned surfaces were prepared by ultraviolet photolithography to investigate the effect of cell–cell interaction on the osteogenic differentiation of human mesenchymal stem cells (MSCs). Single MSCs adhered on the micropatterned surfaces following the micropatterns. Single cells on the isolated, barbell, linear, and honeycomb dot micropatterns had zero, one, two, and three cell–cell interaction partners, respectively. The number of cell–cell interaction of single MSCs was controlled by the different micropatterns, which showed evident effects on actin filament structure assembly and osteogenic differentiation of MSCs. MSCs with two and three interaction partners showed a significantly …
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