作者
Jingchao Li, Jing Zhang, Xinlong Wang, Naoki Kawazoe, Guoping Chen
发表日期
2016
期刊
Nanoscale
卷号
8
期号
15
页码范围
7992-8007
出版商
Royal Society of Chemistry
简介
Gold nanoparticles (AuNPs) have been extensively explored for biomedical applications due to their advantages of facile synthesis and surface functionalization. Previous studies have suggested that AuNPs can induce differentiation of stem cells into osteoblasts. However, how the size and shape of AuNPs affect the differentiation response of stem cells has not been elucidated. In this work, a series of bovine serum albumin (BSA)-coated Au nanospheres, Au nanostars and Au nanorods with different diameters of 40, 70 and 110 nm were synthesized and their effects on osteogenic differentiation of human mesenchymal stem cells (hMSCs) were investigated. All the AuNPs showed good cytocompatibility and did not influence proliferation of hMSCs at the studied concentrations. Osteogenic differentiation of hMSCs was dependent on the size and shape of AuNPs. Sphere-40, sphere-70 and rod-70 significantly …
学术搜索中的文章
J Li, J Zhang, X Wang, N Kawazoe, G Chen - Nanoscale, 2016