作者
S Venkatesh, M Kumar, A Sharma, A Kriplani, AC Ammini, P Talwar, A Agarwal, Rima Dada
发表日期
2010/9
期刊
Archives of gynecology and obstetrics
卷号
282
页码范围
313-318
出版商
Springer-Verlag
简介
Purpose
Primary ovarian insufficiency (POI) is a heterogeneous, multifactorial disorder. Though genetic anomalies, infections, autoimmune disorder and hormonal imbalance are few of the causes of POI, in the majority of patients (50–60%) no etiology has been identified. Mitochondrial bioenergetics and biogenesis play an important role in oocyte and embryo development, whereas mtDNA integrity and content are essential for the normal development of oocytes. ATPase6 helps to maintain the mt genome integrity, and mutations in ATPase6 are associated with overproduction of reactive oxygen species (ROS) in a variety of diseases; however, its role in POI has not been evaluated. Therefore, we planned to evaluate the potential role of ATPase6 gene mutations and associated oxidative stress in idiopathic cases of POI.
Methods
This pilot study included …
学术搜索中的文章
S Venkatesh, M Kumar, A Sharma, A Kriplani… - Archives of gynecology and obstetrics, 2010