作者
Kaitlin C Clark, Fernando A Fierro, Emily Mills Ko, Naomi J Walker, Boaz Arzi, Clifford G Tepper, Heather Dahlenburg, Andrew Cicchetto, Amir Kol, Lyndsey Marsh, William J Murphy, Nasim Fazel, Dori L Borjesson
发表日期
2017/12
期刊
Stem Cell Research & Therapy
卷号
8
页码范围
1-16
出版商
BioMed Central
简介
Background
Adipose-derived mesenchymal stem cells (ASCs) are a promising cell therapy to treat inflammatory and immune-mediated diseases. Development of appropriate pre-clinical animal models is critical to determine safety and attain early efficacy data for the most promising therapeutic candidates. Naturally occurring diseases in cats already serve as valuable models to inform human clinical trials in oncologic, cardiovascular, and genetic diseases. The objective of this study was to complete a comprehensive side-by-side comparison of human and feline ASCs, with an emphasis on their immunomodulatory capacity and transcriptome.
Methods
Human and feline ASCs were evaluated for phenotype, immunomodulatory profile, and transcriptome. Additionally, transwells were used to determine the role of cell-cell contact in ASC-mediated inhibition …
学术搜索中的文章
KC Clark, FA Fierro, EM Ko, NJ Walker, B Arzi… - Stem Cell Research & Therapy, 2017