作者
Rong Fan, George Papatheodoridis, Jian Sun, Hamish Innes, Hidenori Toyoda, Qing Xie, Shuyuan Mo, Vana Sypsa, Indra Neil Guha, Takashi Kumada, Junqi Niu, George Dalekos, Satoshi Yasuda, Eleanor Barnes, Jianqi Lian, Vithika Suri, Ramazan Idilman, Stephen T Barclay, Xiaoguang Dou, Thomas Berg, Peter C Hayes, John F Flaherty, Yuanping Zhou, Zhengang Zhang, Maria Buti, Sharon J Hutchinson, Yabing Guo, Jose Luis Calleja, Lanjia Lin, Longfeng Zhao, Yongpeng Chen, Harry LA Janssen, Chaonan Zhu, Lei Shi, Xiaoping Tang, Anuj Gaggar, Lai Wei, Jidong Jia, William L Irving, Philip J Johnson, Pietro Lampertico, Jinlin Hou
发表日期
2020/12/1
期刊
Journal of hepatology
卷号
73
期号
6
页码范围
1368-1378
出版商
Elsevier
简介
Background & Aims
Hepatocellular carcinoma (HCC) is the leading cause of death in patients with chronic hepatitis. In this international collaboration, we sought to develop a global universal HCC risk score to predict the HCC development for patients with chronic hepatitis.
Methods
A total of 17,374 patients, comprising 10,578 treated Asian patients with chronic hepatitis B (CHB), 2,510 treated Caucasian patients with CHB, 3,566 treated patients with hepatitis C virus (including 2,489 patients with cirrhosis achieving a sustained virological response) and 720 patients with non-viral hepatitis (NVH) from 11 international prospective observational cohorts or randomised controlled trials, were divided into a training cohort (3,688 Asian patients with CHB) and 9 validation cohorts with different aetiologies and ethnicities (n = 13,686).
Results
We developed an HCC risk score, called the aMAP score (ranging from 0 to 100 …
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R Fan, G Papatheodoridis, J Sun, H Innes, H Toyoda… - Journal of hepatology, 2020