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We investigated the cognitive processes underlying inferential reasoning, comparing performance of patients suffering from schizophrenia with that of patients with brain injury in an attempt to understand the nature of the social impairments in schizophrenia. Inferential reasoning on mental and physical states and second-order false belief attribution was assessed in healthy controls, in patients with schizophrenia and in brain trauma patients with predominantly ventromedial prefrontal cortex or dosolateral prefrontal cortex lesions. Our finding that ventromedial prefrontal areas are involved in general inferential reasoning, casts further light on the neural structures implicated in socio-cognitive impairments in schizophrenia.