作者
Abhishek Bhurwal, Michael Makar, Anish Patel, Hemant Mutneja, Akshay Goel, Michal Bartel, Haroon Shahid, Mihajlo Gjeorgjievski, Vinod Rustgi, Avik Sarkar
发表日期
2022/3/1
来源
Digestive diseases and sciences
页码范围
1-11
出版商
Springer US
简介
Introduction
The optimal therapy for bleeding-related gastric varices is still a controversial topic. There is a paucity of literature that comprehensively summarizes the available literature regarding safety and efficacy of thrombin in bleeding gastric varices.
Methods
Four independent reviewers performed a comprehensive review of all original articles published from inception to October 2020, describing the use of thrombin for management of bleeding gastric varices. Primary outcomes were (1) pooled early and late rebleeding rate, (2) pooled gastric variceal related mortality rate, (3) pooled rescue therapy rate, and (4) pooled adverse event rate with the use of thrombin in bleeding gastric varices. The meta-analysis was performed and the statistics were two-tailed. Finally, probability of publication bias was assessed using funnel plots and with Egger’s test …
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A Bhurwal, M Makar, A Patel, H Mutneja, A Goel… - Digestive diseases and sciences, 2022